taxonID	type	format	identifier	references	title	description	created	creator	contributor	publisher	audience	source	license	rightsHolder	datasetID
03F98792895CFFE0FF85C480FD03FD38.taxon	http://purl.org/dc/dcmitype/StillImage	image/png	https://zenodo.org/record/2554792/files/figure.png	https://doi.org/10.5281/zenodo.2554792	Fig. 1 Sampling strategy for Streptomyces from insect microbiomes. Streptomyces were isolated from a wide range of insects and geographies (1445 insects; 10,178 strains; dot size, insects sampled). Streptomyces production of the antifungal mycangimycin (1) in the Southern Pine Beetle system is shown at right. Cyphomycin (2) is a new antifungal described herein. Photo credits: southern pine beetle - Erich G. Vallery; fungus-growing ant – Alexander Wild	Fig. 1 Sampling strategy for Streptomyces from insect microbiomes. Streptomyces were isolated from a wide range of insects and geographies (1445 insects; 10,178 strains; dot size, insects sampled). Streptomyces production of the antifungal mycangimycin (1) in the Southern Pine Beetle system is shown at right. Cyphomycin (2) is a new antifungal described herein. Photo credits: southern pine beetle - Erich G. Vallery; fungus-growing ant – Alexander Wild	2019-12-31	Chevrette, Marc G.;Carlson, Caitlin M.;Ortega, Humberto E.;Thomas, Chris;Ananiev, Gene E.;Barns, Kenneth J.;Book, Adam J.;Cagnazzo, Julian;Carlos, Camila;Flanigan, Will;Grubbs, Kirk J.;Horn, Heidi A.;Hoffmann, Michael;Klassen, Jonathan L.;Knack, Jennifer J.;Lewin, Gina R.;McDonald, Bradon R.;Mulle, Laura;Melo, Weilan G. P.;Pinto-Tomás, Adrián A.;Schmitz, Amber;Wendt-Pienkowski, Evelyn;Wildman, Scott;Zhao, Miao;Zhang, Fan;Bugni, Tim S.;Andes, David R.;Pupo, Monica T.;Currie, Cameron R.		Zenodo	biologists	Chevrette, Marc G.;Carlson, Caitlin M.;Ortega, Humberto E.;Thomas, Chris;Ananiev, Gene E.;Barns, Kenneth J.;Book, Adam J.;Cagnazzo, Julian;Carlos, Camila;Flanigan, Will;Grubbs, Kirk J.;Horn, Heidi A.;Hoffmann, Michael;Klassen, Jonathan L.;Knack, Jennifer J.;Lewin, Gina R.;McDonald, Bradon R.;Mulle, Laura;Melo, Weilan G. P.;Pinto-Tomás, Adrián A.;Schmitz, Amber;Wendt-Pienkowski, Evelyn;Wildman, Scott;Zhao, Miao;Zhang, Fan;Bugni, Tim S.;Andes, David R.;Pupo, Monica T.;Currie, Cameron R.			
03F987928955FFEBFC51C6D8FD28FB0B.taxon	http://purl.org/dc/dcmitype/StillImage	image/png	https://zenodo.org/record/2554792/files/figure.png	https://doi.org/10.5281/zenodo.2554792	Fig. 1 Sampling strategy for Streptomyces from insect microbiomes. Streptomyces were isolated from a wide range of insects and geographies (1445 insects; 10,178 strains; dot size, insects sampled). Streptomyces production of the antifungal mycangimycin (1) in the Southern Pine Beetle system is shown at right. Cyphomycin (2) is a new antifungal described herein. Photo credits: southern pine beetle - Erich G. Vallery; fungus-growing ant – Alexander Wild	Fig. 1 Sampling strategy for Streptomyces from insect microbiomes. Streptomyces were isolated from a wide range of insects and geographies (1445 insects; 10,178 strains; dot size, insects sampled). Streptomyces production of the antifungal mycangimycin (1) in the Southern Pine Beetle system is shown at right. Cyphomycin (2) is a new antifungal described herein. Photo credits: southern pine beetle - Erich G. Vallery; fungus-growing ant – Alexander Wild	2019-12-31	Chevrette, Marc G.;Carlson, Caitlin M.;Ortega, Humberto E.;Thomas, Chris;Ananiev, Gene E.;Barns, Kenneth J.;Book, Adam J.;Cagnazzo, Julian;Carlos, Camila;Flanigan, Will;Grubbs, Kirk J.;Horn, Heidi A.;Hoffmann, Michael;Klassen, Jonathan L.;Knack, Jennifer J.;Lewin, Gina R.;McDonald, Bradon R.;Mulle, Laura;Melo, Weilan G. P.;Pinto-Tomás, Adrián A.;Schmitz, Amber;Wendt-Pienkowski, Evelyn;Wildman, Scott;Zhao, Miao;Zhang, Fan;Bugni, Tim S.;Andes, David R.;Pupo, Monica T.;Currie, Cameron R.		Zenodo	biologists	Chevrette, Marc G.;Carlson, Caitlin M.;Ortega, Humberto E.;Thomas, Chris;Ananiev, Gene E.;Barns, Kenneth J.;Book, Adam J.;Cagnazzo, Julian;Carlos, Camila;Flanigan, Will;Grubbs, Kirk J.;Horn, Heidi A.;Hoffmann, Michael;Klassen, Jonathan L.;Knack, Jennifer J.;Lewin, Gina R.;McDonald, Bradon R.;Mulle, Laura;Melo, Weilan G. P.;Pinto-Tomás, Adrián A.;Schmitz, Amber;Wendt-Pienkowski, Evelyn;Wildman, Scott;Zhao, Miao;Zhang, Fan;Bugni, Tim S.;Andes, David R.;Pupo, Monica T.;Currie, Cameron R.			
03F987928955FFEBFC51C6D8FD28FB0B.taxon	http://purl.org/dc/dcmitype/StillImage	image/png	https://zenodo.org/record/2554800/files/figure.png	https://doi.org/10.5281/zenodo.2554800	Fig. 5 Insect-associated Streptomyces are a source of active antimicrobials. a Fractionated extracts from insect microbiomes are active in multiple murine models of drug-resistant infection. Less infective burden is seen in intraperitoneally treated mice after 8 h of infection. Each dot represents a unique fraction in one mouse study. (n = 15, 11, and 8 for C. albicans, E. coli, and P. aeruginosa models, respectively; center, median; box, upper and lower quantiles; whiskers, 1.5× interquartile range. b Most fractions from insect microbiomes show no hemolysis in cell-based assays. Safe indicates no toxicity at>100× concentration associated with efficacy. c The antifungal cyphomycin is produced by Streptomyces isolated from d the fungus-growing ant Cyphomyrmex sp. Photo credit: Alexander Wild e Cyphomycin-containing fractions show potency against the ant pathogen Escovopsis sp. (top left, bottom). f Purified cyphomycin exhibits potency against resistant pathogens. g Mouse candidiasis (C. albicans) models showcase reduced infection and a dose-like response to cyphomycin. Dots indicate individual mice	Fig. 5 Insect-associated Streptomyces are a source of active antimicrobials. a Fractionated extracts from insect microbiomes are active in multiple murine models of drug-resistant infection. Less infective burden is seen in intraperitoneally treated mice after 8 h of infection. Each dot represents a unique fraction in one mouse study. (n = 15, 11, and 8 for C. albicans, E. coli, and P. aeruginosa models, respectively; center, median; box, upper and lower quantiles; whiskers, 1.5× interquartile range. b Most fractions from insect microbiomes show no hemolysis in cell-based assays. Safe indicates no toxicity at>100× concentration associated with efficacy. c The antifungal cyphomycin is produced by Streptomyces isolated from d the fungus-growing ant Cyphomyrmex sp. Photo credit: Alexander Wild e Cyphomycin-containing fractions show potency against the ant pathogen Escovopsis sp. (top left, bottom). f Purified cyphomycin exhibits potency against resistant pathogens. g Mouse candidiasis (C. albicans) models showcase reduced infection and a dose-like response to cyphomycin. Dots indicate individual mice	2019-12-31	Chevrette, Marc G.;Carlson, Caitlin M.;Ortega, Humberto E.;Thomas, Chris;Ananiev, Gene E.;Barns, Kenneth J.;Book, Adam J.;Cagnazzo, Julian;Carlos, Camila;Flanigan, Will;Grubbs, Kirk J.;Horn, Heidi A.;Hoffmann, Michael;Klassen, Jonathan L.;Knack, Jennifer J.;Lewin, Gina R.;McDonald, Bradon R.;Mulle, Laura;Melo, Weilan G. P.;Pinto-Tomás, Adrián A.;Schmitz, Amber;Wendt-Pienkowski, Evelyn;Wildman, Scott;Zhao, Miao;Zhang, Fan;Bugni, Tim S.;Andes, David R.;Pupo, Monica T.;Currie, Cameron R.		Zenodo	biologists	Chevrette, Marc G.;Carlson, Caitlin M.;Ortega, Humberto E.;Thomas, Chris;Ananiev, Gene E.;Barns, Kenneth J.;Book, Adam J.;Cagnazzo, Julian;Carlos, Camila;Flanigan, Will;Grubbs, Kirk J.;Horn, Heidi A.;Hoffmann, Michael;Klassen, Jonathan L.;Knack, Jennifer J.;Lewin, Gina R.;McDonald, Bradon R.;Mulle, Laura;Melo, Weilan G. P.;Pinto-Tomás, Adrián A.;Schmitz, Amber;Wendt-Pienkowski, Evelyn;Wildman, Scott;Zhao, Miao;Zhang, Fan;Bugni, Tim S.;Andes, David R.;Pupo, Monica T.;Currie, Cameron R.			
